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Journal / Developmental Biology / X-ray Diffraction of Intact Murine Skeletal…
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Developmental Biology

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JoVE Journal Developmental Biology
X-ray Diffraction of Intact Murine Skeletal Muscle as a Tool for Studying the Structural Basis of Muscle Disease
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X-ray Diffraction of Intact Murine Skeletal Muscle as a Tool for Studying the Structural Basis of Muscle Disease

Article DOI: 10.3791/59559-v • 08:26 min • July 18th, 2019
July 18th, 2019 •
1, 1
1BioCAT, Dept. of Biological Sciences, Illinois Institute of Technology

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We present detailed protocols for performing small-angle X-ray diffraction experiments using intact mouse skeletal muscles. With the wide availability of transgenic mouse models for human diseases, this experimental platform can form a useful test bed for elucidating the structural basis of genetic muscle diseases

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X-ray Diffraction Intact Murine Skeletal Muscle Structural Basis Muscle Disease Physiological Conditions Physiological Processes High Resolution Structural Information Myopathies Therapeutic Strategies Extensor Digitorum Longus Soleus Muscles Small Animals Motor Force Transducer Biphasic Current Stimulator Data Acquisition Control System Ringer's Solution Dissecting Dish
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