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Immunology and Infection

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JoVE Journal Immunology and Infection
Uso do invertebrado Galleria mellonella como modelo de infecção para estudo do complexo Mycobacterium tuberculosis
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Uso do invertebrado Galleria mellonella como modelo de infecção para estudo do complexo Mycobacterium tuberculosis

Article DOI: 10.3791/59703-v • 09:23 min • June 30th, 2019
June 30th, 2019 •
*1, *1, 1,2, 1, 3, *1, *1
1Section of Pediatric Infectious Diseases and Allergy, Department of Medicine, Imperial College London, 2Department of Pharmacy, National University of Singapore, 3MRC Centre for Molecular Bacteriology and Infection, Department of Medicine, Imperial College London
* These authors contributed equally

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A Galleria mellonella foi recentemente estabelecida como um modelo de infecção reprodutível, barato e eticamente aceitável para o complexo Mycobacterium tuberculosis . Aqui nós descrevemos e demonstramos as etapas tomadas para estabelecer a infecção bem sucedida de G. mellonella com o Lux bioluminescente do Mycobacterium bovis BCG .

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Imunologia e infecção Galleria mellonella micobactérias tuberculose Mycobacterium bovis BCG Lux modelo de infecção interações hospedeiro-patógeno complexo Mycobacterium tuberculosis hemócitos
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