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Journal / Immunology and Infection / Um modelo de roedor induzido pela TNBS para…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Um modelo de roedor induzido pela TNBS para estudar o papel patogênico do estresse mecânico na doença de Crohn
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Um modelo de roedor induzido pela TNBS para estudar o papel patogênico do estresse mecânico na doença de Crohn

Article DOI: 10.3791/63499-v • 05:08 min • March 1st, 2022
March 1st, 2022 •
*1, *1, *1, 2, 1
1Department of Internal Medicine, the University of Texas Medical Branch, 2Department of Pathology, the University of Texas Medical Branch
* These authors contributed equally

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O presente protocolo descreve o desenvolvimento de um modelo de colite semelhante a Crohn em roedores. A inflamação transmural leva à estenose no local de instilação do TNBS, e o alargamento mecânico é observado no segmento proximal à estenose. Essas mudanças permitem estudar o estresse mecânico na colite.

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Imunologia e Infecção Questão 181
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