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Design af en biokompatibel Drug-Eluting tracheal stent i mus med Laryngotracheal stenose
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis
DOI:

08:26 min

January 21, 2020

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Chapters

  • 00:04Title
  • 01:19Rapamycin Preparation in Poly (l-lactide)-poly (epsilon-caprolatcone) (PLLA-PCL)
  • 01:56Rapamycin-Eluting PLLA-PCL Murine Airway Stent Creation
  • 03:08Laryngotracheal Stenosis Induction
  • 04:50Transoral PLLA-PCL Stent Placement
  • 05:45Histologic Sample Preparation
  • 06:26Results: Representative Tracheal Stent Biocompatibility Assessment
  • 07:23Conclusion

Summary

Automatic Translation

Laryngotracheal stenose resultater fra patologisk ar deposition, der kritisk indsnævrer trakeal luftvejene og mangler effektive medicinske behandlinger. Ved hjælp af en PLLA-PCL (70% poly-L-lactide og 30% polycaprolactone) stent som et lokalt lægemiddel fremføringssystem, kan potentielle terapier, der tager sigte på at nedsætte ar-spredningen i luftrøret, undersøgt.

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