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JoVE Journal Cancer Research
Sistema de cocultura multidimensional para modelar la progresión del carcinoma escamoso pulmonar
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Sistema de cocultura multidimensional para modelar la progresión del carcinoma escamoso pulmonar

Article DOI: 10.3791/60644-v • 07:53 min • March 17th, 2020
March 17th, 2020 •
1, 1, 1, 1
1Oncology R&D group, Pfizer Worldwide Research and Development

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Se desarrolló un sistema modelo in vitro para capturar los cambios arquitectónicos del tejido durante la progresión del carcinoma escamoso pulmonar (LUSC) en un cocultivo tridimensional (3D) con fibroblastos asociados al cáncer (CAC). Este sistema organoide proporciona una plataforma única para investigar las funciones de diversos cambios tumorales-intrínsecos y extrínsecos que modulan el fenotipo tumoral.

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Cancer Research Número 157 cocultura 3D cáncer de pulmón fibroblastos asociados al cáncer morfogénesis acinar organoides tumorales
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