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多维共同培养系统模拟肺鳞癌进展

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Cancer Research

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JoVE Journal Cancer Research

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

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多维共同培养系统模拟肺鳞癌进展

DOI:

10.3791/60644-v

•

07:53 min

•

March 17, 2020

•

Shuang Chen, Andreas Giannakou, Jonathon Golas, Kenneth G. Geles

¹Oncology R&D group,Pfizer Worldwide Research and Development

Chapters

00:05Introduction
00:52Plating TUM622 Cells in the Extracellular Matrix for 3D Culturing
03:523D Coculturing of TUM622 Cells and CAFs (Cancer Associated Fibroblasts) in the Extracellular Matrix
05:39Results: Growth and Morphology
06:58Conclusion

Summary

Automatic Translation

开发了一个体外模型系统，用于捕捉与癌症相关成纤维细胞（CAF）共同培养的三维（3D）共同培养中肺鳞状癌（LUSC）进展期间的组织结构变化。该器官系统提供了一个独特的平台来研究各种肿瘤细胞内在和外在变化的作用，调节肿瘤表型。

Tags

3D Coculture Lung Squamous Cell Carcinoma Tumor-stroma Interactions Tumor Morphology Tumor Progression Basement Membrane Matrix TUM622 Cells Cancer-associated Fibroblasts Drug Treatment

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