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JoVE Journal Cancer Research
Système de coculture multidimensionnel pour modéliser la progression du carcinome pulmonaire
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Système de coculture multidimensionnel pour modéliser la progression du carcinome pulmonaire

Article DOI: 10.3791/60644-v • 07:53 min • March 17th, 2020
March 17th, 2020 •
1, 1, 1, 1
1Oncology R&D group, Pfizer Worldwide Research and Development

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Un système de modèle in vitro a été développé pour capturer des changements architecturaux de tissu pendant le carcinome squamous de poumon (LUSC) progression dans une co-culture 3 dimensions (3D) avec des fibroblastes cancer-associés (CAFs). Ce système organoïde fournit une plate-forme unique pour étudier les rôles de divers changements tumoraux-intrinsèques et extrinsèques qui modulent le phénotype tumoral.

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Cancer Research 3D coculture cancer du poumon fibroblastes associés au cancer morphogenèse acinar organoïdes tumoraux
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