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JoVE Journal Cancer Research
Flerdimensionella coculture system för att modellera Lung Skivepitelcancer Progression
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Flerdimensionella coculture system för att modellera Lung Skivepitelcancer Progression

Article DOI: 10.3791/60644-v • 07:53 min • March 17th, 2020
March 17th, 2020 •
1, 1, 1, 1
1Oncology R&D group, Pfizer Worldwide Research and Development

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Ett in vitro-modellsystem utvecklades för att fånga vävnadarkitektoniska förändringar under lungskivepiteli (LUSC) progression i en 3-dimensionell (3D) co-kultur med cancer-associerade fibroblaster (CAFs). Detta organoidsystem ger en unik plattform för att undersöka rollerna av olika tumör cell-inneboende och extrinsic förändringar som modulerar tumör fenotyp.

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Cancer Forskning 3D coculture lungcancer cancer-associerade fibroblaster acinar morfogenes tumör organoider
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