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Multidimensionaal Coculture System model Long Plaveisel Carcinoom Progressie
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Multidimensionaal Coculture System model Long Plaveisel Carcinoom Progressie

Article DOI: 10.3791/60644-v • 07:53 min • March 17th, 2020
March 17th, 2020 •
1, 1, 1, 1
1Oncology R&D group, Pfizer Worldwide Research and Development

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Een in vitro model systeem werd ontwikkeld om weefsel architectonische veranderingen vast te leggen tijdens long plaveisel carcinoom (LUSC) progressie in een 3-dimensionale (3D) co-cultuur met kanker-geassocieerde fibroblasten (CAFs). Dit organoïde systeem biedt een uniek platform om de rollen van diverse tumorcel-intrinsieke en extrinsieke veranderingen te onderzoeken die het tumorfenotype moduleren.

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Kankeronderzoek nummer 157 3D-cocultuur longkanker kanker-geassocieerde fibroblasten acinaire morfogenese tumororganoïden
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