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Inducir lesiones hepáticas agudas en ratas a través de tetracloruro de carbono (CCl4) Exposición a través de un tubo orogástrico
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Inducir lesiones hepáticas agudas en ratas a través de tetracloruro de carbono (CCl4) Exposición a través de un tubo orogástrico

Article DOI: 10.3791/60695-v • 06:12 min • April 28th, 2020
April 28th, 2020 •
*1, *1, 2, 3, 1, 1, 4, 1, 1, 1
1Department of Anesthesiology and Critical Care, Soroka Medical Center, Ben-Gurion University of the Negev, 2Department of Anesthesiology, Yale University School of Medicine, 3Department of Neurosurgery, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, 4Department of Ophthalmology, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev
* These authors contributed equally

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Este protocolo describe un método común y factible para inducir lesiones hepáticas agudas (ALI) a través de la exposición de CCl4 a través de un tubo orogástrico. La exposición a CCl4 induce ALI a través de la formación de especies reactivas de oxígeno durante su biotransformación en el hígado. Este método se utiliza para analizar la fisiopatología de ALI y examinar diferentes estrategias hepatoprotectoras.

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Medicina Número 158 lesión hepática aguda (ALI) tetracloruro de carbono (CCl4),lesión hepática daño hepático modelo de rata toxina
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