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Uso de Caenorhabditis elegans para detectar interacciones de chaperonas específicas del tejido
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Uso de Caenorhabditis elegans para detectar interacciones de chaperonas específicas del tejido

Article DOI: 10.3791/61140-v • 06:55 min • June 7th, 2020
June 7th, 2020 •
1, 1, 1, 1
1Department of Life Sciences, Ben-Gurion University of the Negev

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Para estudiar las interacciones chaperona-chaperona y chaperona-sustrato, realizamos pantallas de interacción sintética en Caenorhabditis elegans utilizando interferencia de ARN en combinación con mutaciones leves o sobreexpresión de chaperonas y monitoreamos la disfunción proteica específica del tejido a nivel del organismo.

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Biología Número 160 Caenorhabditis elegans chaperona interacciones genéticas proteostasis ARNi pantalla sensible a la temperatura
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