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Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions
 

Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions

Article DOI: 10.3791/61140-v
June 7th, 2020

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Summary June 7th, 2020

To study chaperone-chaperone and chaperone-substrate interactions, we perform synthetic interaction screens in Caenorhabditis elegans using RNA interference in combination with mild mutations or over-expression of chaperones and monitor tissue-specific protein dysfunction at the organismal level.

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