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小鼠干粉配方的内经管理

JoVE Journal
Medicine

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JoVE Journal Medicine

Intratracheal Administration of Dry Powder Formulation in Mice

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小鼠干粉配方的内经管理

DOI:

10.3791/61469-v

•

07:55 min

•

July 25, 2020

•

Yingshan Qiu, Qiuying Liao, Michael Y.T. Chow², Jenny K.W. Lam

¹Department of Pharmacology and Pharmacy, LKS Faculty of Medicine,The University of Hong Kong, ²Advanced Drug Delivery Group, Sydney Pharmacy School, Faculty of Medicine and Health,The University of Sydney

Chapters

00:04Introduction
01:22Fabrication of Dry Powder Insufflator and Loading of Dry Powder
02:36Intubation
04:17Powder Administration
05:25Results: Optimization of Intratracheal Administration of mRNA Formulation
07:23Conclusion

Summary

Automatic Translation

吸入干粉配方在治疗呼吸系统疾病方面有很大的潜力。在进入人类研究之前，有必要在前科研究中评估干粉配方的功效。提出了一种简单而非侵入性的方法，通过体外路线对小鼠的干粉进行管理。

Tags

Intratracheal Administration Dry Powder Formulation Mice Insufflator Pulmonary Absorption Bioavailability Therapeutic Effects Pre-clinical Animal Models Intubation Static Charges Gel Loading Pipette Tip Weighing Paper Syringe Anesthesia BALB/c Mouse Optical Fiber Guiding Cannula

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