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Journal / Immunology and Infection / Differentiering af monocytter til fænocypisk…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Differentiering af monocytter til fænocypisk forskellige makrofager efter behandling med human navlestrengsblod stamceller (CB-SC)-Afledte Exosomer
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Differentiering af monocytter til fænocypisk forskellige makrofager efter behandling med human navlestrengsblod stamceller (CB-SC)-Afledte Exosomer

Article DOI: 10.3791/61562-v • 09:20 min • November 12th, 2020
November 12th, 2020 •
1,2, 1, 1, 2, 1
1Center for Discovery and Innovation, Hackensack Meridian Health Center, 2Department of Chemistry and Chemistry Biology, Stevens Institute of Technology

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Exosome ansøgning er et nyt værktøj til udvikling af lægemidler og regenerativ medicin. Vi etablerer en exosome isolation protokol med høj renhed til at isolere exosomer fra nye identificerede stamceller kaldet CB-SC for mekanistiske undersøgelser. Vi har også coculture CB-SC-afledte exosomer med menneskelige monocytter, hvilket fører til deres differentiering i fænocypisk forskellige makrofager.

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Immunologi og infektion CB-SC Stem Cell Educator (SCE) terapi exosomer monocyt type 2 makrofag differentiering immunmodulering
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