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Antibiotika effekt test i en Ex vivo Model af Pseudomonas aeruginosa og Staphylococcus aureus Biofilms i cystisk fibrose Lung
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung

Antibiotika effekt test i en Ex vivo Model af Pseudomonas aeruginosa og Staphylococcus aureus Biofilms i cystisk fibrose Lung

DOI:
10.3791/62187-v

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09:26 min

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January 22, 2021

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, , , , ,
1School of Life Science,University of Warwick, 2Institute of Microbiology and Infection,University of Birmingham, 3Warwick Antimicrobial Screening Facility, School of Life Science,University of Warwick

Chapters

  • 00:04Introduction
  • 00:52Dissection and Infection of Ex Vivo Pig Lung (EVPL) Tissue
  • 04:45Determination of Antibiotic Efficacy
  • 06:39Results: Screening Bacterial Isolates for Antibiotic Susceptibility with the EVPL Model
  • 08:49Conclusion

Summary

Automatic Translation

Automatic Translation

Denne arbejdsgang kan bruges til at udføre antibiotika modtagelighed test ved hjælp af en etableret ex vivo model af bakteriel biofilm i lungerne hos personer med cystisk fibrose. Anvendelsen af denne model kan øge den kliniske validitet af MBEC -assays (minimal koncentration af biofilmudryddelse).

Tags

Antibiotic EfficacyPseudomonas AeruginosaStaphylococcus AureusBiofilmsCystic Fibrosis LungEx Vivo ModelBronchioleDMEM RPMI 1640Antibiotic Susceptibility Testing

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