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Immunology and Infection

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Studying Microbial Communities In Vivo

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways

Article DOI: 10.3791/53218-v 06:43 min January 13th, 2016
January 13th, 2016



While in vitro study of host-pathogen interactions allow the characterization of specific immune responses, in vivo models are required to observe the effects of complex responses. Using Candida albicans exposure followed by Pseudomonas aeruginosa-mediated lung infection, we established a murine model of microbial interactions involved in ventilator-associated pneumonia pathogenicity.


Microbial Communities In Vivo Host-mediated Interaction Candida Albicans Pseudomonas Aeruginosa Pathogen Interactions Cross-talk Interspecies Dialect Clinical Relevance Intranasal Installation Fungus CFU PBS Hypotonic Mouse Fungal Suspension Pipette Nostrils Inhalation Recovery Euthanized Animal
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