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Bioengineering

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JoVE Journal Bioengineering
Rastreios de toxicidade em organoides da retina humana para descoberta farmacêutica
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Rastreios de toxicidade em organoides da retina humana para descoberta farmacêutica

Article DOI: 10.3791/62269-v • 07:45 min • March 4th, 2021
March 4th, 2021 •
1,2, 1,2, 1,2, 1,2
1Lowy Medical Research Institute, 2The Scripps Research Institute

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Aqui apresentamos um protocolo passo-a-passo para gerar organoides humanos maduros da retina e utilizá-los em um ensaio de toxicidade de fotorreceptores para identificar candidatos farmacêuticos para a doença degenerativa retiniana relacionada à idade telangiectasia macular tipo 2 (MacTel).

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Este mês em JoVE Edição 169 organoide da retina organoide degeneração da retina MacTel esfingolipídio fotorreceptor fenofibrato coloração TUNEL triagem de drogas toxicidade lipídica
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