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使用妊娠期心理社会压力的Murine模型作为母亲和婴儿精神障碍的翻译相关范式

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Behavior

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JoVE Journal Behavior

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Please note that all translations are automatically generated. Click here for the English version.

使用妊娠期心理社会压力的Murine模型作为母亲和婴儿精神障碍的翻译相关范式

DOI:

10.3791/62464-v

•

06:39 min

•

June 13, 2021

•

Sandra P. Zoubovsky^2,3, Akil Wilder, Louis Muglia^2,3

¹Molecular Developmental Biology Program,Cincinnati Children’s Hospital Medical Center, ²Division of Human Genetics,Cincinnati Children’s Hospital Medical Center, ³Department of Pediatrics,University of Cincinnati College of Medicine, ⁴Division of Veterinary Services,Cincinnati Children’s Hospital Medical Center

Chapters

00:04Introduction
01:04Performing the Chronic Psychosocial Stress (CGS) Paradigm
04:19Results: Effects of Chronic Psychosocial Stress on Dams and Pups
05:51Conclusion

Summary

Automatic Translation

慢性社会心理压力（CGS）范式利用小鼠怀孕期间的临床相关压力源来模拟母亲和婴儿的精神疾病。在此，我们提供了一个逐步应用 CGS 范式和下游评估来验证此模型的程序。

Tags

Keywords: Murine Model Psychosocial Stress Pregnancy Psychiatric Disorders Maternal Mental Health Adverse Infant Development Developmental Origins Of Adult Disease Chronic Gestational Stress (CGS) Paradigm Foreign Objects Predator Odor Cage Tilt Frequent Bedding Changes Bedding Removal

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