Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Sandra P. Zoubovsky; Akil Wilder; Louis Muglia

doi:10.3791/62464

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Brug af en Murine Model af psykosocial stress under graviditet som et translationelt relevant paradigme for psykiatriske lidelser hos mødre og spædbørn

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

JoVE Journal
Behavior

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JoVE Journal Behavior

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Brug af en Murine Model af psykosocial stress under graviditet som et translationelt relevant paradigme for psykiatriske lidelser hos mødre og spædbørn

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3,090 Views

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06:39 min

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June 13, 2021

DOI:

10.3791/62464-v

DOI:

10.3791/62464-v

•

06:39 min

June 13, 2021

•

3074 Views

Sandra P. Zoubovsky^1,2,3, Akil Wilder⁴, Louis Muglia^1,2,3

¹Molecular Developmental Biology Program,Cincinnati Children’s Hospital Medical Center ²Division of Human Genetics,Cincinnati Children’s Hospital Medical Center ³Department of Pediatrics,University of Cincinnati College of Medicine ⁴Division of Veterinary Services,Cincinnati Children’s Hospital Medical Center

Summary

Den kroniske psykosociale stress (CGS) paradigme beskæftiger klinisk relevante stressfaktorer under graviditet hos mus til model psykiatriske lidelser hos mødre og spædbørn. Her tilbyder vi en trinvis procedure for anvendelse af CGS-paradigme- og downstream-vurderingerne for at validere denne model.