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Journal / Biochemistry / Fingeravtrykk Kardiolipin i Leukocytter ved…
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Biochemistry

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JoVE Journal Biochemistry
Fingeravtrykk Kardiolipin i Leukocytter ved massespektrometri for en rask diagnose av barthsyndrom
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Fingeravtrykk Kardiolipin i Leukocytter ved massespektrometri for en rask diagnose av barthsyndrom

Article DOI: 10.3791/63552-v • 06:48 min • March 23rd, 2022
March 23rd, 2022 •
*1, *2, 2, 2
1Medical School, Swansea University, 2Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro
* These authors contributed equally

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Denne protokollen viser hvordan du får et massespektrometrisk "fingeravtrykk" av leukocytt kardiolipin for diagnostisering av Barth syndrom. Vurderingen av forhøyet monolysocardilipin til kardiolipinforhold diskriminerer pasienter med Barth syndrom fra kontroll hjertesviktpasienter med 100% følsomhet og spesifisitet.

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