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JoVE Journal Bioengineering
Cellulær affinitet af partikelstabiliseret emulsion for at øge antigeninternalisering
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Cellulær affinitet af partikelstabiliseret emulsion for at øge antigeninternalisering

Article DOI: 10.3791/64406-v • 10:06 min • September 2nd, 2022
September 2nd, 2022 •
*1,2,3, *3,4, 3,4, 3, 1,2
1Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology, 2Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 3State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 4University of Chinese Academy of Sciences
* These authors contributed equally

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For rationelt at designe effektive adjuvanser udviklede vi poly-mælkesyre-co-glykolsyre-nanopartikelstabiliseret Pickering-emulsion (PNPE). PNPE havde unik blødhed og en hydrofob grænseflade til potent cellulær kontakt og tilbød antigenbelastning med højt indhold, hvilket forbedrede leveringssystemets cellulære affinitet til antigenpræsenterende celler og inducerede effektiv internalisering af antigener.

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