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Journal / Bioengineering / Tri-layered Electrospinning to Mimic Native…
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Bioengineering

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JoVE Journal Bioengineering
Tri-layered Electrospinning to Mimic Native Arterial Architecture using Polycaprolactone, Elastin, and Collagen
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Tri-layered Electrospinning to Mimic Native Arterial Architecture using Polycaprolactone, Elastin, and Collagen: A Preliminary Study

Article DOI: 10.3791/2084-v • 10:47 min • January 4th, 2011
January 4th, 2011 •
1, 1, 2, 3, 1
1Department of Biomedical Engineering, Virginia Commonwealth University, 2Department of Anatomy and Neurobiology, Virginia Commonwealth University, 3Department of Cardiovascular Surgery, University Hospital of Geneva

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The aim of this study was to mimic the native three layered architecture of the arterial wall. To accomplish this, electrospinning was employed with the use of a 3-1 (input-output) nozzle and blends of polycaprolactone, elastin, and collagen.

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Tri-layered Electrospinning Native Arterial Architecture Polycaprolactone Elastin Collagen Mechanical Properties Multi-layered Electrospun Conduit Tissue Regeneration Uniaxial Tensile Testing Dynamic Compliance Suture Retention Burst Strength Modulus Range Circumferential Wall Stress Mathematical Modeling
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