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JoVE Journal
Medicine

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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
 

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Article DOI: 10.3791/3947-v 10:01 min July 10th, 2012
July 10th, 2012

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Summary

Obliterative bronchiolitis is the key impediment to the long-term survival of lung transplant recipients and the lack of a robust preclinical model precludes examining obliterative bronchiolitis immunopathogenesis. Unlike other solid organ transplants, vascularized mouse lung transplantation has only recently been developed. Here we show our independently developed obliterative bronchiolitis model after murine orthotopic single-lung transplantation.

Tags

Obliterative Bronchiolitis Murine Model Orthotopic Lung Transplantation Allo-rejection Ischemia-reperfusion Injury Rat Model Large Animal Model Knockout Rats Transgenic Rats Tracheal Allograft Model Histopathologic Features Vasculature Conducting Airways Pathologic Features Mouse Lung Transplants
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