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Zebrafish as a Model to Assess the Teratogenic Potential of Nitrite
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Immunology and Infection
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JoVE Journal Immunology and Infection
Zebrafish as a Model to Assess the Teratogenic Potential of Nitrite

Zebrafish as a Model to Assess the Teratogenic Potential of Nitrite

DOI:
10.3791/53615-v

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07:29 min

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February 16, 2016

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, , , ,
1Department of Biology,Indiana University of Pennsylvania

Chapters

  • 00:05Title
  • 00:42Harvesting Embryos
  • 02:19Treating Embryos
  • 05:53Results: Exposure of Zebrafish to Sodium Nitrite and Sodium Ntrate
  • 06:51Conclusion

Summary

Automatic Translation

Automatic Translation

Exposure to teratogens may cause birth defects. Zebrafish are useful for determining the teratogenic potential of chemicals. We demonstrate the utility of zebrafish by exposing embryos to various levels of nitrite and also at different times of exposure. We show that nitrite can be toxic and cause severe developmental defects.

Tags

ZebrafishDevelopmental ToxicologyTeratogenic EffectsNitriteEmbryonic DevelopmentExternal DevelopmentWild-type StrainsMatingFertilizationEthanolSodium Nitrite

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