Journal
/
Cancer Research
/
Determining the Optimal Inhibitory Frequency for Cancerous Cells Using Tumor Treating Fields (TTFields)
JoVE Journal
Cancer Research
This content is Free Access.
JoVE Journal Cancer Research
Determining the Optimal Inhibitory Frequency for Cancerous Cells Using Tumor Treating Fields (TTFields)

Determining the Optimal Inhibitory Frequency for Cancerous Cells Using Tumor Treating Fields (TTFields)

DOI:
10.3791/55820-v

•

08:14 min

•

May 04, 2017

•

, , , , , , , , , , , ,
1Preclinical Research Department,Novocure Ltd., Haifa, Israel, 2Novocure Ltd., Haifa, Israel, 3Novocure GmbH, Lucerne, Switzerland

Chapters

  • 00:05Title
  • 01:00Experimental Setup
  • 02:32TTFields Application
  • 05:17Evaluation of TTFields Effect
  • 06:04Results: Frequency-dependent Growth Inhibitory Effect of TTFields
  • 06:58Conclusion

Summary

Automatic Translation

Automatic Translation

Tumor Treating Fields (TTFields) are an effective anti-tumor treatment modality delivered via the continuous, noninvasive application of low-intensity, intermediate-frequency, alternating electric fields. TTFields application to cell lines using a TTFields in vitro application system allows for the determination of the optimal frequency that leads to the highest reduction in cell counts.

Tags

Tumor Treating Fields (TTFields)In VitroCancer CellsInhibitory FrequencyCell Growth InhibitionU-87 MG CellsDMEM MediumCell SuspensionCoverslipGrowth MediumRefrigerated IncubatorElectric Field IntensityTTFields GeneratorPre-clinical IdentificationCombined TreatmentChemotherapyRadiation Therapy

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

Capture and Release of Viable Circulating Tumor Cells from Blood

The Drosophila Imaginal Disc Tumor Model: Visualization and Quantification of Gene Expression and Tumor Invasiveness Using Genetic Mosaics

Characterization of Tumor Cells Using a Medical Wire for Capturing Circulating Tumor Cells: A 3D Approach Based on Immunofluorescence and DNA FISH

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry

Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells

Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells

Generation of Zebrafish Larval Xenografts and Tumor Behavior Analysis

Read Article