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Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
JoVE Journal
Chemistry
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JoVE Journal Chemistry
Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
DOI:

11:09 min

August 01, 2018

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Chapters

  • 00:04Title
  • 00:38Manual Solid-Phase Peptide Synthesis
  • 02:42Formation of Thioether Linker by On-Resin Cyclization
  • 05:29Thioether Linker Formation via Intermolecular Thio-ene Reaction and Peptide Cyclization via Macrolactamization
  • 07:02Solution-Phase Formation of a Vinyl Sulfide Linker
  • 08:41Results: Thioether- and Vinyl Sulfide-Tethered Cyclic Peptides
  • 10:42Conclusion

Summary

Automatic Translation

We present a protocol for the construction of thioether/vinyl sulfide-tethered helical peptides using photo-induced thiol-ene/thiol-yne hydrothiolation.

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