Journal
/
Chemistry
/
Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
JoVE Journal
Chemistry
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Chemistry
Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

DOI:
10.3791/57356-v

•

11:09 min

•

August 01, 2018

•

, , ,
1Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School

Chapters

  • 00:04Title
  • 00:38Manual Solid-Phase Peptide Synthesis
  • 02:42Formation of Thioether Linker by On-Resin Cyclization
  • 05:29Thioether Linker Formation via Intermolecular Thio-ene Reaction and Peptide Cyclization via Macrolactamization
  • 07:02Solution-Phase Formation of a Vinyl Sulfide Linker
  • 08:41Results: Thioether- and Vinyl Sulfide-Tethered Cyclic Peptides
  • 10:42Conclusion

Summary

Automatic Translation

Automatic Translation

We present a protocol for the construction of thioether/vinyl sulfide-tethered helical peptides using photo-induced thiol-ene/thiol-yne hydrothiolation.

Tags

ThioetherVinyl SulfideHelical PeptidesPhoto-induced Thiol-ene/yne Hydro-thiolationRink Amide MBHA ResinFmoc DeprotectionHCTUDIPEATrityl DeprotectionSolid-phase Peptide Synthesis

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Preparing Silica Aerogel Monoliths via a Rapid Supercritical Extraction Method

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry

Epitaxial Growth of Perovskite Strontium Titanate on Germanium via Atomic Layer Deposition

Insights into the Interactions of Amino Acids and Peptides with Inorganic Materials Using Single-Molecule Force Spectroscopy

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Fabrication and Testing of Catalytic Aerogels Prepared Via Rapid Supercritical Extraction

Synthesis of Substrate-Bound Au Nanowires Via an Active Surface Growth Mechanism

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species

Read Article