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JoVE Journal Developmental Biology
En familjär hyperkolesterolemi mänskliga levern chimär musmodell med inducerade pluripotenta stamceller-derived hepatocyter
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En familjär hyperkolesterolemi mänskliga levern chimär musmodell med inducerade pluripotenta stamceller-derived hepatocyter

Article DOI: 10.3791/57556-v • 10:56 min • September 15th, 2018
September 15th, 2018 •
*1,2,6, *2, *3, 1,2, 2, 2, 4,5, 4,5, 2, 4,5, 4,5, 4,5, 4,5, 3, 4,5,7, 1,2,6,7
1Department of Medicine, University of Hong Kong-Shenzhen Hospital, 2The Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, 3School of Biomedical Sciences, Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, 4Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, 5Laboratory of RNA, Chromatin, and Human Disease, CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 6Research Centre of Heart, Brain, Hormone, and Healthy Ageing, Li Ka Shing Faculty of Medicine, University of Hong Kong, 7Hong Kong-Guangdong Stem Cell and Regenerative Medicine Research Centre, University of Hong Kong and Guangzhou Institutes of Biomedicine and Health
* These authors contributed equally

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Här presenterar vi ett protokoll för att generera en människa lever chimära musmodell av familjär hyperkolesterolemi med mänskliga inducerade pluripotenta stamceller-derived hepatocyter. Detta är en värdefull modell för att testa nya terapier för hyperkolesterolemi.

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Fråga 139 hepatocyter Familial hyperkolesterolemi utvecklingsbiologi mänskliga levern chimära möss inducerade pluripotenta stamceller LDL-receptorn statiner PCSK9 antikroppar
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