Journal
/
Neuroscience
/
Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
JoVE Journal
Neuroscience
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Neuroscience
Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

DOI:
10.3791/60027-v

•

05:01 min

•

August 16, 2019

•

,
1Department of Surgery,Northwestern University

Chapters

  • 00:04Title
  • 00:42Pre-Surgical Preparation
  • 01:24Controlled Cortical Traumatic Brain Injury (TBI) Induction
  • 03:02Surgical Site Closure and Post-Operative Care
  • 03:39Results: Representative Gross, Histologic, and MRI Evaluation of Mouse Brain Tissue After Severe TBI
  • 04:16Conclusion

Summary

Automatic Translation

Automatic Translation

Here we describe a protocol for the induction of murine traumatic brain injury via an open-head controlled cortical impact.

Tags

Murine ModelControlled Cortical ImpactTraumatic Brain InjuryStereotaxic FrameCraniectomyDura MaterImpactor TipBiomechanical ParametersReproducible Injury

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

A Novel In Vitro Model of Blast Traumatic Brain Injury

Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries

Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice

Induction of Diffuse Axonal Brain Injury in Rats Based on Rotational Acceleration

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

A Metric Test for Assessing Spatial Working Memory in Adult Rats Following Traumatic Brain Injury

Electromagnetic Controlled Closed-Head Model of Mild Traumatic Brain Injury in Mice

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Read Article