Valve-sparing aortic root replacement has the advantage of preserving the patient's own aortic valve. The complexity of the reported techniques to date restricts their use to a limited number of cardiac surgeons. This protocol describes step-by-step a standardized technique reproducible by a greater number of cardiac surgeons.
Despite the obvious advantages of the preservation of a normal aortic valve during aortic root replacement, the complexity of valve sparing procedures prevents a number of cardiac surgeons from incorporating them into their practice. The aim of this protocol is to describe a simplified and user-friendly technique of an aortic valve-sparing root replacement (VSRR) procedure by re-implantation of the aortic valve. Proper selection of patients and limitations of the technique are discussed.
In 54 consecutive patients, normal appearing aortic valves were re-implanted in a commercially available polyester prosthesis with pre-shaped sinuses by a simplified and standardized technique. Placement of the first row of the proximal suture line, choice of the prosthesis size, and adjustment of the height of the commissures of the patient to the fixed height of the sinus portion of the prosthesis were slightly modified from the reference techniques with the aim of increasing its feasibility for use by other cardiac surgeons. Early mortality and morbidity as well as 5-year survival, freedom from aortic valve reoperation, and freedom from recurrent moderate regurgitation were collected in all patients.
Thirty-day mortality, re-sternotomy for bleeding, re-sternotomy for mediastinitis, and the incidence of stroke were very low, 1.8% for each (1 of 54). No patient required permanent pace-maker implantation. At 5 years, survival, freedom from aortic valve reoperation, and freedom from recurrent moderate regurgitation were 97.5%, 95.2%, and 91.6%, respectively.
Mid-term results of our standardized technique of re-implantation of the aortic valve for valve-sparing aortic root replacement are very good and compare with more complex techniques reported by experienced surgeons. By following the present protocol of the standardized re-implantation technique, a greater number of cardiac surgeons can perform this procedure with comparable good results.
During the past twenty years, the surgical treatment of aortic root aneurysm with normal or near-normal aortic cusps has evolved thanks to a series of surgical procedures aiming at preservation of the native aortic valve1,2,3,4,5. Valve-sparing aortic root replacement is basically accomplished either by re-implantation of the aortic valve inside a synthetic graft1,3,4,6 or by a remodeling technique which restores the physiological anatomy of the aortic root2. Despite the obvious advantages of the preservation of a normal aortic valve during aortic root replacement, many cardiac surgeons replace the aortic valve with either mechanical or biological valve substitutes. According to the Society of Thoracic Surgeons database, only 14% of patients who underwent aortic root replacement in the United States between 2004 and 2010 received a valve-sparing procedure7.
In the original re-implantation technique, the aortic valve is sutured inside a tubular horizontally crimped synthetic graft8. Although this technique stabilizes the aortic annulus, it eliminates the sinuses of Valsalva. In order to recreate the sinuses of Valsalva, this technique has undergone several modifications by its inventor as well as other authors9. A variation of this technique has been proposed by Rama et al., in which the remnants of the aortic wall supporting the commissures are sutured into longitudinal openings made in the tubular polyethylene terephthalate graft4.
The remodeling technique achieves a more anatomical reconstruction of the aortic root but leaves the aortic annulus unsupported and exposed to future dilatation. Various surgical techniques have been designed to tailor the aortic annular base in aortic root remodeling, including sub-commissural aortic annuloplasty10, circumferential suture annuloplasty11, and internal or external annuloplasty by synthetic partial or complete ring12.
Despite the excellent results reported by experienced authors, the complexity and periodical modifications of these procedures hamper their reproducibility by other cardiac surgeons and thus prevent a number of suitable patients to benefit from retaining their own aortic valve. In order to enhance the reproducibility of the re-implantation technique, we have used a commercially available synthetic graft with an uncrimped, pre-shaped sinus portion and simplified the implantation technique. The aim of this protocol is to describe in detail this standardized and reproducible technique with particular emphasis on the management of the first row of the proximal suture line and of the placement of the commissures inside the graft and the choice of the graft size. Early outcomes and mid-term results are presented. Proper selection of patients for and limitations of this procedure are discussed.
The protocol follows the institutional guidelines of the human research ethics committee.
1. Pre-selection of the Patient
2. Preparation for Surgery
NOTE: Preparation for surgery follows the institutional guidelines and recommendations for adult cardiac surgery patients.
3. Surgery
4. Post-operative Patient Care
Statistical Analysis:
Continuous variables are presented as mean ± standard deviation and categorical variables as percentages. Kaplan-Meier curves are calculated for survival, freedom from aortic valve reoperation, and freedom from recurrent moderate regurgitation using a commercially available software package.
Patient Population:
VSRR according to the present protocol was performed in 54 consecutive patients with aortic root aneurysm ≤60 mm and normal or near-normal appearing aortic valve (Table 1). The majority of patients were adult males in stable clinical condition (Table 1). Thirty-two patients underwent isolated VSRR whereas twenty-two had a VSRR combined with other cardiac surgical procedures (Table 2). For patients undergoing isolated VSRR, cross-clamp and cardiopulmonary bypass times were shorter than for those having combined operations (Table 2).
Early Outcomes:
Thirty-day mortality, re-sternotomy for bleeding, re-sternotomy for mediastinitis, and the incidence of stroke were very low, 1.8% for each (1 of 54). No patient required permanent pace-maker implantation.
Mid-term Survival:
There were 2 deaths during the follow-up period. One patient died 4 years after the operation of sudden death. The echocardiographic study one year before had shown trivial aortic regurgitation and normal ejection fraction. A second patient died 6 years after the operation following a car accident. This patient had stable moderate aortic regurgitation with stable left ventricular dimensions and without impairment of the left ventricular function on successive follow-up echocardiographic examinations. Thus, the 5 year and 10 year survival in this series were 97.5% and 92.5%, respectively (Figure 5A).
Mid-term Freedom from Reoperation on Aortic Valve:
Mid-term Freedom from Reoperation on Aortic Valve: Two of the four patients with recurrent moderate aortic regurgitation underwent reoperation because of progredient left ventricular dilatation. One of these two patients had been reoperated early on after one week for mediastinitis. At reoperation for valve replacement 36 months later, the plication of the right coronary cusp was torn, presumably due to accompanying bacteremia during his mediastinitis. At the second valve operation, he received a full-root stentless aortic valve replacement and survived. The second patient was reoperated for aortic valve replacement 49 months after the initial operation. At reoperation, the free edge of the plicated left and right coronary cusps was fibrotic and considerably retracted. He received a mechanical aortic valve replacement through the synthetic prosthesis and survived. Thus, the freedom reoperation for aortic valve replacement at 5 years and 10 years was 95.2% and 93%, respectively (Figure 5B).
Mid-term Freedom from Moderate Aortic Regurgitation:
Four patients developed moderate (2+) aortic regurgitation14 during the follow-up period. All these patients had tricuspid aortic valves. Only one of these four patients left the operating room with mild insufficiency at the end of the operation. Because of his stable asymptomatic clinical status and echocardiographic surveillance parameters (left ventricular function and dimensions) he is being followed-up without reoperation. Two of the four patients underwent reoperation on the aortic valve. The fourth patient was the one who died following a car accident. Thus, the freedom from moderate aortic regurgitation at 5 years and 10 years were 91.6% and 90%, respectively (Figure 5C).
Figure 1: Schematic view of the heart after establishment of the cardiopulmonary bypass. (A) The ascending aorta is cross-clamped below the origin of the innominate artery. (B) Coronary buttons are detached from the aortic wall and the sinuses are excised. Please click here to view a larger version of this figure.
Figure 2: Distribution of the first row of mattress sutures for the proximal anastomosis. (A) Mattress sutures are passed circumferentially through the aorto-ventricular junction in a horizontal plane 1 – 2 mm under the nadir of the aortic valve. (B) Care is taken to avoid passing sutures through the membranous septum. Please click here to view a larger version of this figure.
Figure 3: Implantation of the pre-shaped sinus graft. (A) The mattress sutures of the first row of the proximal anastomosis are then passed through the tailored proximal skirt of the graft. (B) The second row of sutures fixes the remnants of the aortic wall inside the graft. Please click here to view a larger version of this figure.
Figure 4: Completion of the implantation of the graft. The coronary ostia are connected to the graft and the distal anastomosis completed. Please click here to view a larger version of this figure.
Figure 5: Kaplan-Meier curves at 10 years. (A) Survival. (B) Freedom from reoperation on the aortic valve. (C) Freedom from recurrent moderate aortic regurgitation Please click here to view a larger version of this figure.
Age (years) | 61 ±11 | |
Male sex | 46 (85%) | |
Diagnosis | ||
Aneurysm | 48 (89%) | |
Type A Dissection | 6 (11%) | |
NYHA class | ||
I | 31 (57%) | |
II | 7 (13%) | |
III | 10 (19%) | |
IV | 6 (11%) | |
Emergency | 7 (13%) | |
EF | ||
≥50% | 45 (83%) | |
>35%, <50% | 6 (11%) | |
≤35% | 3 (6%) | |
Pre-operative aortic regurgitation | ||
0 | 10 (19%) | |
1+ | 9 (17%) | |
2+ | 18 (33%) | |
3+ | 17 (31%) | |
Aorto-ventricular junction (mm) | 26.2 ±1.3 | |
Valsalva sinus (mm) | 49.2 ±9.2 |
Table 1: Patients' characteristics. Patients' characteristics are depicted in this table. The decision to consider a valve sparing root replacement is based on the diameter of the aorto-ventricular junction less than 28 mm and sinuses of Valsalva less than 60 mm.
Isolated VSRR | VSRR associated with other operations | Total | |
N (%) | 32 (59%) | 22 (41%) | 54 |
cusp repair | 3 | 11 | 14 |
Graft size | |||
28 | 2 | 2 | 4 |
30 | 5 | 9 | 14 |
32 | 25 | 11 | 36 |
Cross-clamp time (min) | 159 ±14 | 192 ±41 | |
Cardiopulmonary bypass time (min) | 217 ±24 | 258 ±55 | |
VSRR = valve-sparing root replacement |
Table 2: Intra-operative data in patients undergoing isolated or combined valve sparing root replacement. Cross-clamp and cardio-pulmonary bypass times are shorter for isolated valve sparing root replacement.
In patients presenting with aortic root aneurysm with normal or near-normal aortic cusps, valve-sparing aortic root replacement is a more physiological and hence attractive alternative to composite graft replacement of the aorta and the aortic valve with mechanical or tissue valve. In this protocol, we describe a simplified technique of valve-sparing aortic root replacement by re-implantation of the aortic valve. In contrast to the majority of the previously reported techniques3,8, in this protocol the mattress sutures of the first row are distributed asymmetrically in order to avoid injury to the membranous septum. Moreover, in the protocol these mattress sutures are not reinforced over pledgets. The rationale to omit pledgets for these sutures is based on the intention to reduce the risk of interference with the normal movements of the valve not only by direct disturbance at an early stage but also by potential granuloma formation around them at a later stage15. This simplified technique can also be done in patients with thin and pliable bicuspid valves with creation of two corresponding sinuses. In type 0 bicuspid aortic valves, root reimplantation is performed at 180°/180° circumferential orientation16. In type 1 bicuspid aortic valves the 210°/150° circumferential orientation of conjoint and non-conjoint leaflets is respected while reimplanting the valve into the neosinuses16.
Two distinct procedures, known as remodeling and re-implantation techniques, have been devised by pioneer cardiac surgeons to address VSRR procedures1,2. Controversies around the role of the Valsalva sinuses and the long-term fate of the aortic annulus have resulted in several modifications of both techniques, including hand-tailored or fabric creation of neo-sinuses in the synthetic tube1,3,4,6 and various techniques of supporting the aortic annulus10,11,12. In a very recent study17 the pioneer of the re-implantation technique expressed uncertainty about the rationale for hand-tailored creation of neo-sinuses, which he himself had introduced and performed over a long period. As this, his historical series of 333 valve-sparing aortic root replacement procedures includes an initial cohort of patients with tubular grafts without neo-sinuses, an intermediate cohort of patients with hand-tailored neo-sinuses, and a last cohort of patients similar to the first one with tubular grafts without neo-sinuses. In his recent study, creation of neo-sinuses was even associated with the late development of moderate or severe aortic regurgitation in univariate but not on multivariate analysis17. Thus, the wealth of technical modifications of the valve-sparing procedures reported by not only different surgeons but also by the pioneer of the re-implantation technique do not facilitate the decision-making for other cardiac surgeons, having the skills to perform these procedures and to embark in performing this operation7.
Bearing these considerations in mind, we have opted for a simplified and standardized approach to valve-sparing operation. We agree with authors considering that preservation of the aortic sinuses is more physiological and potentially favors the durability of the aortic valve18. We find also that supporting the aortic annulus in all patients may be advantageous since the dynamic of dilatation of the aorto-ventricular junction remains uncertain19. For these reasons, we use a commercially available synthetic graft with pre-shaped, uncrimped sinus portion for re-implantation of the aortic valve in all patients in whom the aortic valve is judged suitable for preservation. Contrary to the opinion that the sinus portion of this graft is spherical and deforms the aorto-ventricular junction17 we find the uncrimped sinus portion of this graft rather conical and suitable for re-implantation of the commissures inside it.
In the protocol, the proximal suture line is performed in standardized fashion in all patients with 12 polyester 2/0 mattress sutures without pledgets, 4 under each cusp. The distribution of these mattress sutures is asymmetric and slightly different from that described by other surgeons1,3. In the present protocol, each sinus is secured with 4 mattress sutures with particular attention not to place any stitch through the membranous septum (Figure 3A, B). Following this concept and staying 1 – 2 mm under the nadir of each sinus in a horizontal plan, we did not have to deplore any injury to the anterior leaflet of the mitral valve, membranous septum, or AV-node. In the largest series of patients undergoing VSRR, the incidence of implantation of permanent pacemaker for complete heart block was 1.5%17.
In some studies, the choice of the graft size has been done by application of complex formulas based on theoretical assumptions of relationship between the diameter of aorto-ventricular junction, height of the cusps, and sinus diameter8,20,21. This complexity is an additional factor contributing to the limited propagation of the re-implantation technique reported by experienced surgeons. It is noteworthy that by applying his formula, David et al. use a narrow range of graft sizes with a mean of 30.7 ±2.8 mm22. Another technical aspect of the technique resides in the pragmatic simplification of the choice of the size of the synthetic graft by using commercially available valve sizers. To choose the size of the graft in this technique, 4 - 6 mm are added to the diameter of the valve sizer that comfortably fits through the aorto-ventricular junction. De Paulis et al. use a similar approach by adding 5 mm to the diameter of the aortic annulus measured by a Hegar dilator19. By this simplification, the mean diameter of the grafts implanted in the series was 31.2 ±1.3 mm, which is very close to 30.4 ±1.4 mm reported by De Paulis19 and to that reported by David22.
It has been claimed that the height of the sinuses of patients may vary and not coincide with the height of the pre-shaped sinus grafts and that this discrepancy could potentially create technical and anatomical difficulties17. In standardized technique presented here, this issue is addressed by tailoring the proximal skirt of the graft following apposition of the commissures at the sino-tubular junction inside of the graft. The proximal sutures are then passed through the tailored proximal skirt of the graft.
The mean diameter of the implanted prosthesis was 31.2 ±1.3 mm in the patients which is 5 – 6 mm larger than the measured mean aortic annulus diameter. However, in the case of aortic annulus dilation beyond 28 mm, the choice of prosthesis size may be done by addition of less than 4-6 mm to the measured aortic annulus and associated to commissural annuloplasty in order to enhance cusp coaptation.
Because of the small numbers and limited follow-up of the present series, the results should be regarded expectantly. Nevertheless, early and mid-term mortalities and morbidities are low and encouraging. Early and late mortalities of 1.8 and 3.8% in our patients compare favorably with those reported by larger series with longer follow-up17,19,23. Likewise, freedom from reoperation and from moderate to severe recurring aortic regurgitation including the patients who underwent reoperation are very good and similar to those observed by the same authors17,19,23. The good results of the presented series are to be ascribed to the simplified technique in selected patients. Ideally, good candidates for re-implantation have moderate dilatation of the sinuses (<55 mm), no or trace aortic regurgitation, and normal or near normal cusp anatomy17. The majority of the patients in this study fell into this description.
As mentioned above, small numbers of patients and limited follow-up period are the main limitations of this study. Nevertheless, following technical considerations of this protocol would allow a greater number of cardiac surgeons to perform VSRR.
The authors have nothing to disclose.
This work was supported by a grant (N° 32117) of the Swiss Cardiovascular Foundation to RT.
Heart surgery infrastructure: | |||
Heart Lung Machine | Stockert | SIII | |
EOPA 24Fr. arterial cannula | Medtronic | 77624 | |
Atrial caval venous cannula 34/48Fr. | Medtronic | 93448 | |
LV vent catheter 17Fr. | Edwards | E061 | |
Antegrade 9Fr. cardioplegia cannula | Edwards | AR012V | |
Retrograde 14Fr. cardioplegia cannula | Edwards | NPC014 | |
Coronary artery ostial cannula 90° | Medtronic | 30155 | |
Coronary artery ostial cannula 45° | Medtronic | 30255 | |
Name | Company | Catalog Number | Comments |
Pre-shaped sinus graft | |||
Cardioroot 28 mm | Maquet | HEWROOT0028 | |
Cardioroot 30 mm | Maquet | HEWROOT0030 | |
Cardioroot 32 mm | Maquet | HEWROOT0032 | |
Name | Company | Catalog Number | Comments |
Electrocautery | Covidien | Force FX | |
Name | Company | Catalog Number | Comments |
Sutures: | |||
Polypropylene 4/0 | Ethicon | 8871H | |
Polypropylene 5/0 | Ethicon | 8870H | |
Polypropylene 6/0 | Ethicon | EH7400H | |
Braided polyesther 2/0 ligature with polybutylate coating | Ethicon | X305H | |
Name | Company | Catalog Number | Comments |
Micro knife Sharpoint | TYCO Healthcare PTY | 78-6900 | |
Name | Company | Catalog Number | Comments |
Drugs: | |||
Midazolam | Roche Pharma | N05CD08 | |
Rocuronium | MSD Merck Sharp & Dohme | M03AC09 | |
Propofol | Fresenius Kabi | N01AX10 | |
Fentanil | Actavis | N01AH01 | |
Heparin | Braun | B01AB01 | |
Protamin | MEDA Pharmaceutical | V03AB14 | |
Name | Company | Catalog Number | Comments |
Instruments: | |||
Cooley vascular aortic clamp | Delacroix-Chevalier | DC40810-16 | |
Dissection forceps Carpentier | Delacroix-Chevalier | DC13110-28 | |
Scissors Metzenbaum | Delacroix-Chevalier | B351751 | |
Needle holder Ryder | Delacroix-Chevalier | DC51130-20 | |
Dissection forceps DeBakey | Delacroix-Chevalier | DC12000-21 | |
Micro needle holder Jacobson | Delacroix-Chevalier | DC50002-21 | |
Micro scisors Jacobson | Delacroix-Chevalier | DC20057-21 | |
Lung retractor | Delacroix-Chevalier | B803990 | |
Allis clamp | Delacroix-Chevalier | DC45907-25 | |
O’Shaugnessy Dissector | Delacroix-Chevalier | B60650 | |
18 blade knife | Delacroix-Chevalier | B130180 | |
Leriche haemostatic clamp | Delacroix-Chevalier | B86555 | |
Name | Company | Catalog Number | Comments |
Data analysis | |||
Kaplan Meier curves | GraphPad | Prism 7 |