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Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System

Article DOI: 10.3791/2241
May 12th, 2011 •
*1, *1, 1
1Department of Surgery, University of Toronto
* These authors contributed equally

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Summary
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May 12th, 2011

Optic Nerve transection is a widely used model of adult CNS injury. Ninety percent of retinal ganglion cells (RGCs) whose axons are completely transected (axotomy) die within 14 days after axotomy. This model is easily amenable to experimental manipulations and highly reproducible.

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