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在实验室老鼠研究求可卡因电击诱导恢复原状的程序
JoVE Journal
Neuroscience
This content is Free Access.
JoVE Journal
Neuroscience
A Procedure for Studying the Footshock-Induced Reinstatement of Cocaine Seeking in Laboratory Rats
Please note that all translations are automatically generated.
Click here for the English version.
在实验室老鼠研究求可卡因电击诱导恢复原状的程序
DOI:
10.3791/2265-v
•
08:54 min
•
January 06, 2011
•
David A. Kupferschmidt
,
Zenya J. Brown
,
Suzanne Erb
1
Psychology
,
University of Toronto Scarborough
Chapters
00:05
Title
00:46
Introduction
01:25
Operant Chambers
02:35
Habituation and Cocaine Self-Administration (SA) Training
04:34
Drug-free Period and Extinction of Cocaine-Trained Behavior
05:42
Reinstatement of Cocaine-Trained Behavior by Footshock Stress
07:02
Representative Lever-Response Results
08:14
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
动物模型复发,被称为复职程序,已被广泛用于研究复发的药物寻求在应力的作用。在这里,我们报告恢复寻求通过在实验室老鼠轻微,间歇性的电动电击急性暴露可卡因诱导的方法。
Tags
Footshock-induced Reinstatement
Cocaine Seeking
Laboratory Rats
Drug Addiction
Relapse
Animal Models
Neurobiology
Phenomenology
Reinstatement Procedures
Drug Self-administration Model
Operant Response
Extinction
Drug Seeking
Training Drug
Drug-associated Cues
Stressor
Acute Non-contingent Exposure
Environmental Stimuli
Stress
Mild Intermittent Electric Footshocks
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