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Murine Model of Allergen Induced Asthma
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Immunology and Infection
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JoVE Journal Immunology and Infection
Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

DOI:
10.3791/3771-v

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08:05 min

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May 14, 2012

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, ,
1Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine,Emory University and Atlanta VA Medical Center

Chapters

  • 00:05Title
  • 01:10Allergen Sensitization and Intratracheal Challenge
  • 03:07Challenge by Nebulization
  • 03:43Determination of Hyperresponsiveness to Methacholine
  • 05:25Measurement of Cellular Infiltration into the Airspace
  • 07:12Differential Analysis of Airway Cells and Serum IgE Quantification in Control and Ovalbumin-treated Mice
  • 07:47Conclusion

Summary

Automatic Translation

Automatic Translation

Experimental mouse models of allergic asthma offer new possibilities for studying disease pathogenesis and developing new therapeutics. These models are well suited to measuring factors governing the allergic immune response, airway inflammation, and pulmonary pathophysiology.

Tags

Murine ModelAllergen-induced AsthmaAsthma PrevalenceAnimal ModelsPathophysiologyTherapeutic TargetsPreclinical TestingOvalbuminIntraperitoneal InjectionNebulizationIntratracheal DeliveryAirway HyperresponsivenessEosinophil-rich Airway InflammationMeasuring Techniques

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