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Immunology and Infection
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In Vivo Imaging Systems (IVIS) Detection of a Neuro-Invasive Encephalitic Virus

In Vivo Imaging Systems (IVIS) Detection of a Neuro-Invasive Encephalitic Virus

Article DOI: 10.3791/4429-v 10:22 min December 2nd, 2012
December 2nd, 2012



Utilizing luciferase and in vivo imaging systems (IVIS) as a novel means to identify disease endpoints before clinical developments occur. IVIS has allowed us to visualize in real time the invasion of encephalitic viruses over multiple days, providing a more accurate disease model for future study. It has also allowed us to identify the potential protective features of antivirals and vaccines faster than currently utilized animal models. The capability to utilize individual animals over multiple time points ensures reduced animal requirements, costs, and overall morbidity to the animals utilized ensuring a more humane and more scientific means of disease study.


In Vivo Imaging Systems (IVIS) Neuro-invasive Encephalitic Virus Imaging Technology Viral Research Animal Models Scientific Accuracy Reduction Of Animal Usage Statistical Accuracy Vaccine Efficacy Studies Morbidity And Mortality Endpoints In Vivo Imaging Systems (IVIS) Firefly Bioluminescent Enzyme Central Nervous System (CNS) Encephalitic Virus Murine Model Intranasal Infection TC83-Luc Attenuated Venezuelan Equine Encephalitis Virus Luciferase Gene
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