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Journal / Immunology and Infection / Establishment and Optimization of a High…
JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
Establishment and Optimization of a High Throughput Setup to Study Staphylococcus epidermidis and Mycobacterium marinum Infection as a Model for Drug Discovery
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Journal (Immunology and Infection)
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Establishment and Optimization of a High Throughput Setup to Study Staphylococcus epidermidis and Mycobacterium marinum Infection as a Model for Drug Discovery

Article DOI: 10.3791/51649 • 10:19 min • June 26th, 2014
June 26th, 2014 •
*1, *2, 3, 1, 2, 1, 1
1Institute of Biology, Leiden University, 2ZF-screens BV, 3Life Science Methods BV
* These authors contributed equally

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Summary
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This video article describes the high throughput pipeline that has been successfully established to infect and analyze large numbers of zebrafish embryos providing a new powerful tool for compound testing and drug discovery using a whole animal vertebrate organism.

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High Throughput Setup Study Staphylococcus Epidermidis Mycobacterium Marinum Infection Model Drug Discovery Zebrafish Preclinical Phase Whole Animal Model High Throughput Screening Bridge The Gap Cell Based Assays In Vivo Validation Mammalian Models Compounds Passing Through Rodent Models Pipeline In Vivo Model System Synchronous Embryos Flexible Pipeline Improve Resolution Analysis Zebrafish Together With Innovative High Throughput Technologies Drug Testing And Discovery Transgenic Lines Mode Of Action
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