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Chapters
- 00:05Title
- 02:48Synthesis of Iridium(III) Complex
- 04:04Interactions of Ir1 with Various Amino Acids and Titration of Ir1 with BNT-II
- 05:55Real-time Kinetic Analysis of the Ir1/BNT-II System Using Biolayer Interferometry
- 08:31On-bead Detection of BNT-II and rcHRP-II with Ir1
- 10:41Results: Luminescent Detection of Histidine Rich Protein-II
- 11:48Conclusion
Robust detection reagents are of increasing necessity for developing new malaria diagnostic tools. An iridium(III) probe was designed that emits long-lasting luminescent signal in the presence of a histidine-rich malarial protein biomarker. Detection of the protein either in solution or immobilized on a magnetic particle affords flexibility in application.
