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执行永久远端大脑中与老年大鼠颈总动脉闭塞研究皮层缺血具有持续残疾
JoVE Journal
Medicine
This content is Free Access.
JoVE Journal
Medicine
Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability
Please note that all translations are automatically generated.
Click here for the English version.
执行永久远端大脑中与老年大鼠颈总动脉闭塞研究皮层缺血具有持续残疾
DOI:
10.3791/53106-v
•
09:11 min
•
February 23, 2016
•
Christina Wayman*
1,2
,
Denise A. Duricki*
1,2
,
Lisa A. Roy
,
Barbara Haenzi
,
Shi-Yen Tsai
,
Gwendolyn Kartje
5,6
,
John S. Beech
,
Diana Cash
,
Lawrence Moon
1
Wolfson Centre for Age-Related Diseases
,
King’s College London, University of London
,
2
Department of Neuroimaging, James Black Centre, Institute of Psychiatry
,
King’s College London, University of London
,
3
Institute of Neuroscience and Psychology, Wellcome Surgical Institute, College of Medical, Veterinary and Life Sciences
,
University of Glasgow, Glasgow
,
4
Research Service
,
Edward Hines Jr. VA Hospital
,
5
Neurology Service
,
Edward Hines Jr. VA Hospital
,
6
Department of Molecular Pharmacology and Therapeutics, Neuroscience Research Institute
,
Loyola University Chicago
,
7
Department of Oncology, The Gray Institute for Radiation, Oncology and Biology
,
University of Oxford
Chapters
00:05
Title
01:03
Stroke Surgery
06:48
Confirmation of Infarct and Sample Size Calculation
07:39
Results: Representative Micro and Macroanatomical Effects of MCA Occlusion on Cerebral Function in the Elderly Rat
08:32
Conclusion
Summary
Automatic Translation
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Automatic Translation
在这里,我们提出了一个协议,以生产中老年雌性大鼠永久远端大脑中动脉闭塞的颈动脉闭塞的同时产生大量的皮质梗死和持续的赤字。我们采用结构MRI 24小时,行程8周后显示病灶大小的确认。
Tags
Permanent Middle Cerebral Artery Occlusion
Carotid Artery Occlusion
Elderly Rat Model
Cortical Ischemia
Sustained Disability
MRI
Infarct
Behavioral Deficits
Surgical Procedure
Common Carotid Artery
Vagus Nerve
Cortical Ischemia
Stroke Model
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