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En fenotip Karakterizasyonu: Niceleme Matters Neden<em> Drosophila</em> Larva Nöromüsküler Junction
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Neuroscience
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JoVE Journal Neuroscience
Why Quantification Matters: Characterization of Phenotypes at the Drosophila Larval Neuromuscular Junction
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En fenotip Karakterizasyonu: Niceleme Matters Neden<em> Drosophila</em> Larva Nöromüsküler Junction

DOI:
10.3791/53821-v

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10:41 min

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May 12, 2016

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, ,
1Euan MacDonald Centre for Motor Neurone Disease Research,University of Edinburgh, 2School of Biomedical Sciences,University of Edinburgh

Chapters

  • 00:05Title
  • 01:28Mounting the NMJ Samples
  • 02:48Measuring Nuclei Density within a Muscle Fiber
  • 05:06Shape Analysis of the Muscle Fiber Nuclei
  • 06:523D Volume Renderings of Muscle Fiber Nuclei
  • 08:22Results: Analysis of ALS-like Symptoms
  • 09:38Conclusion

Summary

Automatic Translation

Automatic Translation

Morphology, size and location of intracellular organelles are evolutionarily conserved and appear to directly affect their function. Understanding the molecular mechanisms underlying these processes has become an important goal of modern biology. Here we show how these studies can be facilitated by the application of quantitative techniques.

Tags

Keywords: QuantificationPhenotypesDrosophila Larval Neuromuscular JunctionMorphologySizeDistributionNucleiStriated MusclesMorphometric AnalysisGeneticsDissectionStainingConfocal Imaging3D RenderingVolume RenderingObject Analysis

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