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1The Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology,Taipei Medical University and National Health Research, 2Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology,Taipei Medical University, 3TMU research center for Neurotrauma and Neuroregeneration, College of Medical Science and Technology,Taipei Medical University
Chapters
- 00:05Title
- 01:21Preparation of Micro-osmotic Pump Infusion Systems
- 02:41Intracerebral Ventricular Surgery – Implantation of the Micro-osmotic Pump
- 04:15Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
- 06:04Results: Glucose Metabolism and Insulin Signal Activation
- 07:27Conclusion
Dieses Protokoll untersucht die Rolle der Chemokin (C-C-Motiv) Liganden 5 (CCL5) im Hypothalamus durch die Bereitstellung von Antagonist MetCCL5, in das Gehirn der Maus mit einem Mikro-osmotischen Pumpe Gehirn Infusion System. Diese vorübergehende Hemmung der CCL5 Aktivität unterbrochen Hypothalamus Insulin Signalisierung, Glukoseintoleranz und periphere systemische Insulinsensitivität führen.
