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1The Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology,Taipei Medical University and National Health Research, 2Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology,Taipei Medical University, 3TMU research center for Neurotrauma and Neuroregeneration, College of Medical Science and Technology,Taipei Medical University
Chapters
- 00:05Title
- 01:21Preparation of Micro-osmotic Pump Infusion Systems
- 02:41Intracerebral Ventricular Surgery – Implantation of the Micro-osmotic Pump
- 04:15Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
- 06:04Results: Glucose Metabolism and Insulin Signal Activation
- 07:27Conclusion
Detta protokoll studier chemokine (C-C motiv) ligand 5 (CCL5) i hypotalamus roll genom att leverera en antagonist, MetCCL5, in i musen hjärnan använder ett mikro-osmotic pumpsystem hjärnan infusion. Detta övergående hämning av CCL5 verksamhet avbryts hypotalamus insulin signalering, vilket leder till glukosintolerans och perifera systemiska insulinkänslighet.
