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Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model
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Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

DOI:
10.3791/56476-v

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05:12 min

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September 04, 2017

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, , , ,
1Lab of Cardiovascular Signaling,Centenary Institute, 2Faculty of Medicine, Sydney Medical School,University of Sydney, 3Department of Pharmacology, School of Basic Medical Sciences,Tianjin Medical University, 4Australian Centre for Microscopy & Microanalysis,University of Sydney

Chapters

  • 00:05Title
  • 00:57Induction of Cerebral Cavernous Malformations in Mouse Models
  • 01:38Sample Preparation for Micro-CT Scans
  • 03:15Micro-CT Scan of CCM in the Neonatal Mouse Brain
  • 03:57Results: Rendered 3-D Images Showing CCM Lesions in the Neonatal Mouse
  • 04:34Conclusion

Summary

Automatic Translation

Automatic Translation

This protocol demonstrates the induction of cerebral cavernous malformation disease in a mouse model and uses contrast enhanced micro computed tomography to measure lesion burden. This method enhances the value of established mouse models to study the molecular basis and potential therapies for cerebral cavernous malformation and other cerebrovascular diseases.

Tags

Keywords: Cerebral Cavernous MalformationsNeonatal MiceMicro-CT Imaging4-HTParaformaldehydeLugol’s IodineBrain ImagingVascular Disease

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