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一种研究胆碱能药物早期开发中胆碱能药物中央神经系统药效学作用的计算机测试电池
JoVE Journal
Neuroscience
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JoVE Journal
Neuroscience
A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
Please note that all translations are automatically generated.
Click here for the English version.
一种研究胆碱能药物早期开发中胆碱能药物中央神经系统药效学作用的计算机测试电池
DOI:
10.3791/56569-v
•
07:02 min
•
February 11, 2019
•
Ellen P. Hart
,
Ricardo Alvarez-Jimenez
,
Esther Davidse
,
Robert Jan Doll
,
Adam F. Cohen
,
Joop M.A. Van Gerven
,
Geert Jan Groeneveld
1
Centre for Human Drug Research (CHDR), Leiden
Chapters
00:04
Title
00:36
Adaptive Tracking Test
01:35
Saccadic Eye Movement and Smooth Pursuit Test
03:28
Visual Analog Scale, Body Sway and Visual Verbal Learning Test
05:32
Results: Effect of Placebo, Mecamylamine, and Scopolamine on the Adaptive Tracking Test in Healthy Young Males
06:08
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
一个经过验证的计算机电池的神经心理和神经生理测试被用来研究药效学影响的中枢神经系统在早期阶段的发展。为了证明测试电池, 描述了 mecamylamine 的急性影响和两种激动剂药物逆转这些影响。
Tags
Pharmacodynamic
Central Nervous System
Cholinergic Drugs
Early Phase Drug Development
Neuropsychological
Neurophysiological
Test Battery
Repeated Measurements
Concentration Effects Relationships
Dose Escalation
Computerized Test
Eye Electrodes
EEG
Subject Performance
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