Pentylenetetrazole-Induced Kindling Mouse Model

Journal

Neuroscience

JoVE Journal
Neuroscience

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JoVE Journal Neuroscience

Pentylenetetrazole-Induced Kindling Mouse Model

DOI:

10.3791/56573-v

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07:06 min

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June 12, 2018

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Tadayuki Shimada, Kanato Yamagata

¹Synaptic Plasticity Project,Tokyo Metropolitan Institute of Medical Science

Chapters

00:04Title
00:38Injection of PTZ
01:20Three Chamber Test
04:18Contextual Fear Discrimination
05:29Results: Repetitive Injection of PTZ Induces an Increase in Seizure Severity
06:26Conclusion

Summary

Automatic Translation

This protocol describes a method of chemical kindling with pentylenetetrazole and provides a mouse model of epilepsy. This protocol can also be used to investigate vulnerability to seizure induction and pathogenesis after epileptic seizures in mice.

Pentylenetetrazole-Induced Kindling Mouse Model

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