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一种诱导大鼠抑郁症状行为的新方法

JoVE Journal
Behavior

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JoVE Journal Behavior

A New Method for Inducing a Depression-Like Behavior in Rats

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一种诱导大鼠抑郁症状行为的新方法

DOI:

10.3791/57137-v

•

07:57 min

•

February 22, 2018

•

Vladimir Zeldetz*¹, Dmitry Natanel*², Matthew Boyko, Alexander Zlotnik, Honore N. Shiyntum, Julia Grinshpun, Dmitry Frank, Ruslan Kuts, Evgeni Brotfain, Jochanan Peiser

¹Department of Emergent Medicine, Soroka University Medical Center,Ben-Gurion University of the Negev, ²Division of Anesthesiology and Critical Care, Soroka Medical Center,Ben-Gurion University of the Negev, ³Department of Biophysics and Biochemistry,Oles’ Honchar Dnipro National University

Chapters

00:04Title
00:40Measuring Depression at Baseline
02:31Induction of Depression in Rats
04:03Establishing Depression-contagion in Naïve Rats
04:37Open Field Test
05:08Forced-swim Test
05:50Results: Sucrose Preference, Open Field and Forced Swim Test Performance after Induction of Depression-like Behavior
07:22Conclusion

Summary

Automatic Translation

该协议描述了一种新的模型, 通过这种模式, 健康的大鼠可以在一定时间内收缩抑郁症, periodthrough 感染慢性不可预测的压力大鼠。

Tags

Keywords: Depression Contagion Rat Model Behavioral Field Mechanism Prevention Containment Treatment Therapy Sucrose Preference Test Chronic Unpredictable Stress Housing Food Deprivation Water Deprivation Wet Bedding Continuous Lighting

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