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Developmental Biology
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人诱导多潜能干细胞衍生肝细胞的药物发现方法
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JoVE Journal
Developmental Biology
Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery
Please note that all translations are automatically generated.
Click here for the English version.
人诱导多潜能干细胞衍生肝细胞的药物发现方法
DOI:
10.3791/57194-v
•
12:40 min
•
May 19, 2018
•
Jui-Tung Liu
,
Mary Paige Lamprecht
,
Stephen A. Duncan
1
Department of Regenerative Medicine and Cell Biology
,
Medical University of South Carolina
Chapters
00:04
Title
01:05
Culture of Human Induced Pluripotent Stem Cells
03:39
Differentiation of Human iPSCs to Hepatocyte-like Cells and Small Molecule Screening
09:34
Results: Differentiation of iPSCs and Identification of Small Molecules for Drug Discovery
11:12
Conclusion
Summary
Automatic Translation
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这里提出的协议描述了一个平台, 用于鉴别肝脏疾病的小分子。本文详细介绍了如何将 iPSCs 分化为96井板中具有肝细胞特征的细胞, 并利用细胞筛选出具有潜在治疗活性的小分子。
Tags
Human Induced Pluripotent Stem Cells
Hepatocytes
Liver Disease
High-throughput Screening
Drug Discovery
Cell Differentiation
Ecad
DPBS
Y-27632
EDTA
M Medium
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