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人卵巢组织与工程化内皮细胞联合移植: 一种以细胞为基础的快速灌注与直接分泌的融合策略
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Bioengineering
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JoVE Journal Bioengineering
Co-transplantation of Human Ovarian Tissue with Engineered Endothelial Cells: A Cell-based Strategy Combining Accelerated Perfusion with Direct Paracrine Delivery
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人卵巢组织与工程化内皮细胞联合移植: 一种以细胞为基础的快速灌注与直接分泌的融合策略

DOI:
10.3791/57472-v

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07:40 min

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May 16, 2018

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, , , , , , , ,
1Center for Reproductive Medicine and Infertility,Weill Cornell Medical College, 2Angiocrine Biosciences, Inc., 3Tri-Institutional Stem Cell Derivation Laboratory,Weill Cornell Medical College, 4Joan and Sanford I. Weill Department of Medicine,Weill Cornell Medical College

Chapters

  • 00:04Title
  • 01:06Encapsulation of Ovarian Tissue
  • 03:40Bilateral Oophorectomy and Co-transplantation of Human Ovarian Tissue with Engineered Endothelial Cells into NSG Mice
  • 05:07Results: Co-transplantation of Human Ovarian Tissue with Endothelial Cells
  • 06:57Conclusion

Summary

Automatic Translation

Automatic Translation

对某些患者来说, 保留生育能力的唯一选择是保存卵巢组织。不幸的是, 延迟血管重建破坏卵泡活力。在这里, 我们提出一个协议, 共同移植人卵巢组织与内皮细胞作为一种基于细胞的战略结合加速灌注与直接分泌交付的生物活性分子。

Tags

Co-transplantationEngineered Endothelial CellsCell-based StrategyAccelerated PerfusionParacrine DeliveryXenograftFollicular ActivationFolliculogenesisFibrin ClotAccutaseHemocytometer

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