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68加标记精氨酸甘氨酸 (rgd)-肽的血管生成
JoVE Journal
Medicine
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JoVE Journal Medicine
Preparing a 68Ga-labeled Arginine Glycine Aspartate (RGD)-peptide for Angiogenesis
DOI:

07:48 min

January 07, 2019

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Chapters

  • 00:04Title
  • 00:47Arginine Glycine Aspartate (RGD)-Peptide Radiolabeling
  • 02:42In Vitro Cellular Uptake and Serum Stability
  • 04:17Lipophilicity Determination, Tumor Model Preparation, In Vivo Quantification, and Ex Vivo Biodistribution
  • 06:05Results: Representative 68Ga-RGD-peptide Purification, Radiochemical Purity, and In Vivo Imaging and Ex Vivo Biodistribution Analyses
  • 07:04Conclusion

Summary

Automatic Translation

αvβ3整合素是一种在正在进行血管生成的活化内皮细胞上高度表达的粘附蛋白.因此, 评估整合素的完整性在肿瘤学中具有重要意义。在这里, 我们介绍了一种方法, 准备68ga 标记的辐射肽和一种方法来评估其生物有效性。

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