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基于荧光素酶的大抑癌 (拉图) 生物传感器监测河马信号通路活动
JoVE Journal
Cancer Research
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JoVE Journal Cancer Research
Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
DOI:

07:16 min

September 13, 2018

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Chapters

  • 00:04Title
  • 00:50Investigation of a Putative Regulator of Hippo Signaling Using the LATS-BS
  • 04:07A Screen to Identify Hippo Pathway Regulators Using LATS-BS
  • 05:50Results: LATS-BS Utilized to Measure Activation and Inhibition Effect of a Small Molecule on LATS Kinase Activity
  • 06:22Conclusion

Summary

Automatic Translation

在这里, 我们提出一个基于荧光素酶的生物传感器, 以量化的激酶活性的大抑癌 (拉图)-一个中心激酶在河马信号通路。该生物传感器在基础和平移研究中有不同的应用, 目的是在体外体内对河马通路调节器进行调查。

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