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利用磁性纳米粒子丰富和扩大罕见抗原特异性 t 细胞
JoVE Journal
Engineering
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JoVE Journal Engineering
Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles
DOI:

09:28 min

November 17, 2018

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Chapters

  • 00:04Title
  • 01:27Artificial Antigen Presenting Cell (aAPC) Nanoparticle Formation
  • 03:18Antigen-Specific CD8+ T Cell Enrichment and Expansion
  • 06:59Results: Representative Enrichment and Expansion of Antigen-Specific CD8+ T Cells
  • 08:45Conclusion

Summary

Automatic Translation

抗原特异性 t 细胞由于其频率极低, 很难在治疗中表征或利用。在此, 我们提供了一个协议, 以开发一个磁性粒子, 它可以结合到抗原特异性 t 细胞, 以丰富这些细胞, 然后扩大他们的几百倍, 用于表征和治疗。

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