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神经系统疾病中的脂质组学和转录组学
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Lipidomics and Transcriptomics in Neurological Diseases
DOI:

09:58 min

March 18, 2022

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Chapters

  • 00:04Introduction
  • 00:52Brain Punching
  • 02:20Co-extraction of eCBs and eiCs
  • 04:32Co-extraction of PLs, eCBs and Dual Extraction of RNA and Lipids
  • 07:51Results: Lipidomic and Transcription Profiling in KA-induced Epilepsy
  • 09:27Conclusion

Summary

Automatic Translation

本文提出了一种模块化方案,用于神经系统疾病小鼠模型中的组织脂质组学和转录组学以及血浆脂质组学,靶向炎症和神经元活性下的脂质,膜脂质,下游信使以及脂质功能下的mRNA编码酶/受体。概述了采样,样品处理,提取和定量程序。

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