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用于筛查绝经后心血管功能障碍的外源雌激素治疗的活体雌激素缺乏小鼠模型
JoVE Journal
Biochemistry
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JoVE Journal Biochemistry
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
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用于筛查绝经后心血管功能障碍的外源雌激素治疗的活体雌激素缺乏小鼠模型

DOI:
10.3791/59536-v

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06:18 min

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August 13, 2019

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, ,
1Institute of Medicinal Plant Development (IMPLAD),Chinese Academy of Medical Sciences & Peking Union Medical College, 2Shandong University of Traditional Chinese Medicine

Chapters

  • 00:05Title
  • 00:52Bilateral Ovariectomy
  • 02:22Body Weight, Total Cholesterol (TC), and Triglyceride (TG) Measurement
  • 03:25Aorta Harvest
  • 04:29Results: Representative Effects of Exogenous Estrogens on OVX Mouse Phenotype and Function
  • 05:46Conclusion

Summary

Automatic Translation

Automatic Translation

临床上,更年期妇女雌激素缺乏可能加重脂质紊乱和动脉粥样硬化的发生率。我们通过在apoE-/-小鼠的双背侧切口,通过双边卵巢切除术建立了体内雌激素缺乏模型。小鼠模型适用于绝经后心血管功能障碍的外源雌激素治疗。

Tags

OvariectomyEstrogen DeficiencyAPOE Knockout MiceCardiovascular DysfunctionMenopauseArteriosclerosisExogenous Estrogen TreatmentsPlasma CholesterolTriglycerides

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